Unani medicine is substantially based on Ibn Sina's The Canon of Medicine (11th century). The medical tradition of medieval Islam was introduced to India by the 13th century with the establishment of the Delhi Sultanate and it took its own course of development during the Mughal Empire, influenced by Indian medical teachings of Sushruta and Charaka. Alauddin Khalji (d. 1316) had several eminent physicians (Hakims) at his royal courts. This royal patronage meant development of Unani practice in India, but also of Unani literature with the aid of Indian Ayurvedic physicians.
Unani classical literature consists of thousands of books. According to Unani medicine, management of any disease depends upon the diagnosis of disease. In the diagnosis, clinical features, i.e., signs, symptoms, laboratory features and mizaj (temperament) are important. Any cause or factor is countered by Quwwat-e-Mudabbira-e-Badan (the power of body responsible to maintain health), the failing of which may lead to quantitatively or qualitatively derangement of the normal equilibrium of akhlat (humors) of body which constitute the tissues and organs. This abnormal humor leads to pathological changes in the tissues anatomically and physiologically at the affected site and exhibits the clinical manifestations.
According to WHO, "Pharmacovigilance activities are done to monitor detection, assessment, understanding and prevention of any obnoxious adverse reactions to drugs at therapeutic concentration that is used or is intended to be used to modify or explore physiological system or pathological states for the benefit of recipient." These drugs may be any substance or product including herbs, minerals, etc. for animals and human beings and can even be that prescribed by practitioners of Unani or ayurvedic system of medicine.